NOLVADEX® (tamoxifen citrate) Tablets work by blocking estrogen. In breast tissue, NOLVADEX is an antiestrogen. An antiestrogen or estrogen blocker works by blocking estrogen in breast tissue. While estrogen may not actually cause breast cancer, it may stimulate its growth, feeding the cancer. With estrogen blocked, the cancer cells that need it may not grow at all. In other words, antiestrogens may keep cancer from developing in your breast.

NOLVADEX was initially developed to treat advanced breast cancer. NOLVADEX has been successfully helping save the lives of millions of women with breast cancer for over 20 years.

Today, NOLVADEX is used to treat breast cancer. Nolvadex is not indicated for the treatment of premenopausal, node positive patients. Because it can delay or stop the growth of breast cancer cells, it’s also a welcome option for the management of ductal carcinoma in situ (DCIS) following surgery and radiation. If you’ve had a breast biopsy and are unsure if your outcome might have been DCIS, it’s now vital to speak with your doctor again.

Important safety information for NOLVADEX. Endometrial cancer, pulmonary emboli, and deep-vein thrombosis occurred 3 to 4 times more frequently with NOLVADEX than placebo, but in less than 1% of women. Stroke, cataracts, and cataract surgery occurred more frequently in clinical trials with NOLVADEX than placebo. Most frequently reported adverse reactions were hot flashes, vaginal discharge, and irregular menses.

Women with DCIS who require anticoagulant therapy or have a history of deep-vein thrombosis or pulmonary emboli should not take NOLVADEX. Women who are pregnant or who currently plan to become pregnant should not take NOLVADEX.